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Article

Association analyses of CYP19 gene polymorphisms with height variation in a large sample of Caucasian nuclear families.

Human genetics - 1 Aug 2006

Yang Tie-Lin, Xiong Dong-Hai, Guo Yan, Recker Robert R, Deng Hong-Wen

Abstract excerpt

Human height is a complex trait regulated by multiple genetic and environmental factors. CYP19 (cytochrome P450 19) encodes aromatase, which catalyses the rate-limiting step in the conversion of androgens to estrogens. Deleterious mutations in CYP19 can result in estrogen deficiency that will influence adult height to certain extent. In the present study, we aimed to test the associations between the CYP19 gene...

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Identifiers

PMID: 16733710
DOI: 10.1007/s00439-006-0199-9
PMCID: PMC1829483

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