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Group II p21-activated kinases as therapeutic targets in gastrointestinal cancer

1 Jan 2016

Abstract excerpt

P21-activated kinases (PAKs) are central players in various oncogenic signaling pathways. The six PAK family members are classified into group I (PAK1-3) and group II (PAK4-6). Focus is currently shifting from group I PAKs to group II PAKs. Group II PAKs play important roles in many fundamental cellular processes, some of which have particular significance in the development and progression of cancer. Because of...

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PMID: 26811660
DOI: 10.3748/wjg.v22.i3.1224

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