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Article

Role of FoxO Proteins in Cellular Response to Antitumor Agents

14 Jan 2019

Abstract excerpt

FoxO proteins (FoxOs) are transcription factors with a common DNA binding domain that confers selectivity for DNA interaction. In human cells, four proteins (FoxO1, FoxO3, FoxO4 and FoxO6), with redundant activity, exhibit mainly a positive effect on genes involved in cell cycle, apoptosis regulation and drug resistance. Thus, FoxOs can affect cell response to antitumor agent treatment. Their transcriptional...

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PMID: 30646603
DOI: 10.3390/cancers11010090

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