Article
Primary mammary angiosarcomas harbor frequent mutations in KDR and PIK3CA and show evidence of distinct pathogenesis.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2020
Beca Francisco, Krings Gregor, Chen Yunn-Yi, Hosfield Elizabeth M, Vohra Poonam, Sibley Richard K, Troxell Megan L, West Robert B, Allison Kimberly H, Bean Gregory R
Abstract excerpt
Angiosarcoma (AS) is the most frequent primary sarcoma of the breast but nevertheless remains uncommon, accounting for <0.05% of breast malignancies. Secondary mammary AS arise following radiation therapy for breast cancer, in contrast to primary AS which occur sporadically. Essentially all show aggressive clinical behavior independent of histologic grade and most are treated by mastectomy. MYC amplification is...
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