Patient-partnered multiomics reveals the molecular architecture of angiosarcoma.

doi:10.1038/s41467-026-75810-2

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Article

Patient-partnered multiomics reveals the molecular architecture of angiosarcoma.

Nature communications - 24 Jul 2026

Chu Hoyin, Hollyer Marissa, Borden Brittany A, Reilly Christopher R, Gómez Tejeda Zañudo Jorge, Thomas Beena S, Phelps Kolbe, Pimenta Erica Maria, Han Seunghun, Camp Sabrina Y, Gillani Riaz, Gutierrez Jacob, Lareau Caleb A, Nagy Matthew, Johnson Jeremy, Alao Oyin, Grundman Hadley, Sterlin Lauren, Terzi Will, Sosa Delia, Small Ilan K, McGillicuddy Mary, Alharbi Nouf, Anastasio Elana, Chastain Parker, Bhakhri Priyanka, Hornick Jason L, Choudhry Hani, Diehl Diane M, Van Allen Eliezer M, Wagle Nikhil, Painter Corrie A, AlDubayan Saud

Abstract excerpt

Angiosarcoma is a poorly understood sarcoma due to its high heterogeneity and rarity. Here we show a comprehensive clinical and molecular analysis of a large cohort of 254 angiosarcoma patients through the patient-partnered Angiosarcoma Project. By integrating transcriptomic, somatic, and germline variant data, we find that subcutaneous angiosarcomas frequently exhibit TGF-β and receptor tyrosine kinase signaling...

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