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Article

Hypertonic saline in treatment of pulmonary disease in cystic fibrosis.

TheScientificWorldJournal - 1 Jan 2012

Reeves Emer P, Molloy Kevin, Pohl Kerstin, McElvaney Noel G

Abstract excerpt

The pathogenesis of lung disease in cystic fibrosis is characterised by decreased airway surface liquid volume and subsequent failure of normal mucociliary clearance. Mucus within the cystic fibrosis airways is enriched in negatively charged matrices composed of DNA released from colonizing bacteria or inflammatory cells, as well as F-actin and elevated concentrations of anionic glycosaminoglycans. Therapies...

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Identifiers

PMID: 22645424
DOI: 10.1100/2012/465230
PMCID: PMC3356721

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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