Article

High ionic strength vector formulations enhance gene transfer to airway epithelia

2024-01-23

Abstract excerpt

<h4>ABSTRACT</h4> A fundamental challenge for cystic fibrosis (CF) gene therapy is ensuring sufficient ransduction of airway epithelia to achieve therapeutic correction. Hypertonic saline (HTS) is frequently administered to people with CF to enhance mucus clearance. HTS transiently disrupts epithelial cell tight unctions, but its ability to improve gene transfer has not been investigated. Here we asked if increas...

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Literature Corpus work: bea6ae76-17de-50cc-8ae1-0a6e49c8988b
DOI: 10.1101/2024.01.22.576687

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