Accurate de novo structure prediction of large transmembrane protein domains using fragment-assembly and correlated mutation analysis.

Abstract excerpt

A new de novo protein structure prediction method for transmembrane proteins (FILM3) is described that is able to accurately predict the structures of large membrane proteins domains using an ensemble of two secondary structure prediction methods to guide fragment selection in combination with a scoring function based solely on correlated mutations detected in multiple sequence alignments. This approach has been...

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