Article
A photon-free approach to transmembrane protein structure determination.
Journal of molecular biology - 9 Dec 2011
Soto Cinque S, Hannigan Brett T, DeGrado William F
Abstract excerpt
The structures of membrane proteins are generally solved using samples dissolved in micelles, bicelles, or occasionally phospholipid bilayers using X-ray diffraction or magnetic resonance. Because these are less than perfect mimics of true biological membranes, the structures are often confirmed by evaluating the effects of mutations on the properties of the protein in their native cellular environments....
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