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Article

Symmetry and frustration in protein energy landscapes: a near degeneracy resolves the Rop dimer-folding mystery.

Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2005

Levy Yaakov, Cho Samuel S, Shen Tongye, Onuchic José N, Wolynes Peter G

Abstract excerpt

Protein folding has become one of the best understood biochemical reactions from a kinetic viewpoint. The funneled energy landscape, a consequence of the minimal frustration achieved by evolution in sequences, explains how most proteins fold efficiently and robustly to their functional structure...

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Identifiers

PMID: 15701699
DOI: 10.1073/pnas.0409572102
PMCID: PMC548997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15701699-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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