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Article

Localizing frustration in native proteins and protein assemblies.

Proceedings of the National Academy of Sciences of the United States of America - 11 Dec 2007

Ferreiro Diego U, Hegler Joseph A, Komives Elizabeth A, Wolynes Peter G

Abstract excerpt

We propose a method of quantifying the degree of frustration manifested by spatially local interactions in protein biomolecules. This method of localization smoothly generalizes the global criterion for an energy landscape to be funneled to the native state, which is in keeping with the principle of minimal frustration. A survey of the structural database shows that natural proteins are multiply connected by a...

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Identifiers

PMID: 18077414
DOI: 10.1073/pnas.0709915104
PMCID: PMC2148382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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