pStab: prediction of stable mutants, unfolding curves, stability maps and protein electrostatic frustration.

Abstract excerpt

Summary: We present a web-server for rapid prediction of changes in protein stabilities over a range of temperatures and experimental conditions upon single- or multiple-point substitutions of charged residues. Potential mutants are identified by a charge-shuffling procedure while the stability changes (i.e. an unfolding curve) are predicted employing an ensemble-based statistical-mechanical model. We expect this...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Computational Biology
• Share to Models, Molecular