Article
Characterization of trimethoprim- and sulphisoxazole-resistant Chlamydia trachomatis.
Molecular microbiology - 1 Oct 1994
Wang L L, Henson E, McClarty G
Abstract excerpt
Trimethoprim and sulphisoxazole were used as selective agents in culture to isolate, by a stepwise procedure, a series of Chlamydia trachomatis L2 populations resistant to the cytotoxic effects of the drugs. Two trimethoprim-resistant populations, L2TriR-60 and L2TriR-100, and one sulphonamide-re...
Topics
- Adenosine Triphosphate
- Animals
- Chlamydia trachomatis
- DNA, Bacterial
- Drug Resistance, Microbial
- Fluorouracil
- Guanosine Triphosphate
- L Cells
- Methotrexate
- Mice
- Microbial Sensitivity Tests
- Mutation
- Phenotype
- RNA, Bacterial
- Sulfisoxazole
- Thymidine
- Trimethoprim
- Uracil