Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans.

Gastroenterology - 1 Sept 2012

Bongers Gerold, Muniz Luciana R, Pacer Michelle E, Iuga Alina C, Thirunarayanan Nanthakumar, Slinger Erik, Smit Martine J, Reddy E Premkumar, Mayer Lloyd, Furtado Glaucia C, Harpaz Noam, Lira Sergio A

Abstract excerpt

BACKGROUND & AIMS: Epithelial cancers can be initiated by activating mutations in components of the mitogen-activated protein kinase signaling pathway such as v-raf murine sarcoma viral oncogene homolog B1 (BRAF), v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS), or epidermal growth factor receptor (EGFR). Human intestinal serrated polyps are a heterogeneous group of benign lesions, but some progress...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caco-2 Cells
Share to Colonoscopy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heparin-binding EGF-like Growth Factor

Share to Hyperplasia

Share to Intestinal Neoplasms

Share to Intestinal Polyps

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Source

Open in PubMed Open full text

Identifiers

PMID: 22643351
DOI: 10.1053/j.gastro.2012.05.034
PMCID: PMC3431560

Genes

EGFR
EGF
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans.PMID 22643351Read ↗

Evaluation of EGFR and COX pathway inhibition in human colon organoids of serrated polyposis and other hereditary cancer syndromes.Semantic proximity Read ↗

Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans.Semantic proximity Read ↗

PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine.Semantic proximity Read ↗

KRAS mutations in traditional serrated adenomas from Korea herald an aggressive phenotype.Semantic proximity Read ↗

TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.Semantic proximity Read ↗

BRAF and KRAS mutations in colorectal hyperplastic polyps and serrated adenomas.Semantic proximity Read ↗

FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formationSemantic proximity Read ↗

Tracing origin of serrated adenomas with BRAF and KRAS mutations.Semantic proximity Read ↗

Intestinal phenotype in mice overexpressing a heparin-binding EGF-like growth factor transgene in enterocytes.Semantic proximity Read ↗

Epidermal growth factor receptor signaling is up-regulated in human colonic aberrant crypt foci.Semantic proximity Read ↗

Braf mutation induces rapid neoplastic transformation in the aged and aberrantly methylated intestinal epithelium.Semantic proximity Read ↗

Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.