Article
Intestinal phenotype in mice overexpressing a heparin-binding EGF-like growth factor transgene in enterocytes.
Growth factors (Chur, Switzerland) - 1 Apr 2010
Chen Chun-Liang, Mehta Veela B, Zhang Hong-Yi, Wu Dana, Otabor Iyore, Radulescu Andrei, El-Assal Osama N, Feng Jiexiong, Chen Yan, Besner Gail E
Abstract excerpt
PRIMARY OBJECTIVE: Heparin-binding EGF-like growth factor (HB-EGF) protects the intestine from damage in animals. Future clinical trials of HB-EGF may involve administration of repeated doses of HB-EGF. Since HB-EGF activates EGF receptors which have been implicated in tumor development, we examined the effects of HB-EGF overexpression in the intestine. RESEARCH DESIGN: We generated transgenic (TG) mice in which...
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