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Detection of JAK2 mutations in paraffin marrow biopsies by high resolution melting analysis: identification of L611S alone and in cis with V617F in polycythemia vera.

Leukemia & lymphoma - 1 Dec 2012

Nussenzveig Roberto H, Burjanivova Tatiana, Salama Mohamed E, Ogilvie Natalie W, Marcinek Juraj, Plank Lukas, Agarwal Archana M, Perkins Sherrie L, Prchal Josef T

Abstract excerpt

JAK2 mutations provide an objective major criterion for diagnosis of myeloproliferative neoplasms in the 2008 World Health Organization classification, and are particularly useful for cases of polycythemia vera (PV). High resolution melting analysis (HRM) using DNA from fresh samples for mutation detection in JAK2 exons 12 and 14 has been reported. Here, we describe two new HRM techniques that use both fresh and...

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PMID: 22642932
DOI: 10.3109/10428194.2012.697562

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JAK2

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