Article

MiR-744 facilitates non-small cell lung cancer progression by direct transcriptional regulation and indirect MAPK pathway activation mediated upregulation of C-FOS

2020-08-25

Abstract excerpt

<h4>Background: </h4> Metastasis is the leading cause of lung cancer associated death. Here, we focused on the function and molecular mechanism of miR-744 and its potential clinical application in lung carcinoma. <h4>Methods: </h4>: The clinical cohort and data from TCGA were analyzed for the correlation of miR-744 and outcomes. Multiple NSCLC cell lines and a xenograft model were applied for the functional studie...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 01251fef-4b29-5221-b91b-230d14cfd4b3
DOI: 10.21203/rs.3.rs-63976/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MiR-744 facilitates non-small cell lung cancer progression by direct transcriptional regulation and indirect MAPK pathway activation mediated upregulation of C-FOSDOI 10.21203/rs.3.rs-63976/v1Read

Transcription Factor KLF4: A Potential Biomarker of Non-small Cell Lung Cancertranscription Factor KLF4: A Potential Biomarker of Non-small Cell Lung CancerSemantic proximity Read

MiR-937-3p Promotes Metastasis and Angiogenesis and is Activated by MYC in Lung AdenocarcinomaSemantic proximity Read

The suppressive role of miR-542-5p in NSCLC: the evidence from clinical data and in vivo validation using a chick chorioallantoic membrane modelSemantic proximity Read

Upregulation of microRNA-483-5p Advances Non-small Cell Lung Cancer (NSCLC) Progression via Stifling HIPK2 ExpressionSemantic proximity Read

MiR-1976/NCAPH/P65 axis inhibits the malignant phenotypes of lung adenocarcinoma.Semantic proximity Read

Clinicopathological Significance of Up-Regulated Pir-1366 in NSCLC and its Effect on Tumor Migration and MetastasisSemantic proximity Read

Up-Regulation of Insulin-Like Growth Factor-2 Promotes Cell Proliferation and Migration and is Associated with Bone Metastasis in Non Small Cell Lung Cancer.Semantic proximity Read

CPSF4 promotes tumor-initiating phenotype by enhancing VEGF/NRP2/TAZ signaling in lung cancer.Semantic proximity Read

Fibroblast Growth Factor 11 (FGF11) Promotes Non-small Cell Lung Cancer (NSCLC) Progression by Regulating Hypoxia Signaling PathwaySemantic proximity Read

FOSL2 Positively Regulates TGF-β1 Signalling in Non-Small Cell Lung CancerSemantic proximity Read

Regulation of NSCLC Cell Proliferation By MARCH7 Via the NF-κB and Wnt/β-Catenin Signaling PathwaysSemantic proximity Read

The Role of miRNA-377 as a Tumor Suppressor in Lung Cancer by Negative Regulation of Genes Belonging to ErbB Signaling PathwaySemantic proximity Read