Article
Development of a carbon-14 labeling approach to support disposition studies with a pegylated biologic.
Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2012
Wang Haiqing, Wang Lifei, Cao Kai, Emanuel Stuart L, Morin Paul, Lin Zheng, Shen Guoxiang, Hosbach Jennifer, Zhang Donglu, Bonacorsi Samuel, Rodrigues A David, Yang Zheng
Abstract excerpt
Although it is widely accepted that one can extend the pharmacokinetic half-life of a therapeutic protein by covalent conjugation with polyethylene glycol (PEG), the disposition properties of such biologics have not yet been fully evaluated. Therefore, a novel [¹⁴C]-labeling method was developed that can be applied to a biologic conjugated with PEG through a maleimide-cysteine reaction. The method was used to...
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