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Article

Tumor penetration of gefitinib (Iressa), an epidermal growth factor receptor tyrosine kinase inhibitor.

Molecular cancer therapeutics - 1 Apr 2005

McKillop David, Partridge Elizabeth A, Kemp John V, Spence Mike P, Kendrew Jane, Barnett Sharon, Wood Phillippa G, Giles Petrina B, Patterson Andrew B, Bichat Francis, Guilbaud Nicolas, Stephens Trevor C

Abstract excerpt

The relative distribution of gefitinib-related material in nude mice bearing s.c. human tumor xenografts and in an orthotopic rat lung tumor model was investigated following oral administration (50 mg/kg) of [14C]-gefitinib. Selected tissue samples were monitored for radioactivity by liquid scintillation counting, whereas plasma and tumor extracts were assayed for gefitinib and its major metabolites (M523595 and...

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PMID: 15827338
DOI: 10.1158/1535-7163.MCT-04-0329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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