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Article

Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome.

PLoS genetics - 16 Mar 2007

Zipfel Peter F, Edey Matthew, Heinen Stefan, Józsi Mihály, Richter Heiko, Misselwitz Joachim, Hoppe Bernd, Routledge Danny, Strain Lisa, Hughes Anne E, Goodship Judith A, Licht Christoph, Goodship Timothy H J, Skerka Christine

Abstract excerpt

Atypical hemolytic uremic syndrome (aHUS) is associated with defective complement regulation. Disease-associated mutations have been described in the genes encoding the complement regulators complement factor H, membrane cofactor protein, factor B, and factor I. In this study, we show in two independent cohorts of aHUS patients that deletion of two closely related genes, complement factor H-related 1 (CFHR1) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17367211
DOI: 10.1371/journal.pgen.0030041
PMCID: PMC1828695

Genes

CFHR1
CFHR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome.PMID 17367211Read ↗

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