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Macrophage extracellular traps require peptidylarginine deiminase 2 and 4 and are a source of citrullinated antigens bound by rheumatoid arthritis autoantibodies

26 Feb 2024

Abstract excerpt

Introduction: Anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis, but the sources of citrullinated antigens as well as which peptidylarginine deiminases (PADs) are required for their production remain incompletely defined. Here, we investigated if macrophage extracellular traps (METs) could be a source of citrullinated proteins bound by APCAs, and if their formation requires PAD2...

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Identifiers

PMID: 38476240
DOI: 10.3389/fimmu.2024.1167362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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