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Molecular Pathways: Involving Microenvironment Damage Responses in Cancer Therapy Resistance

23 May 2012

Abstract excerpt

The armamentarium of therapeutics used to treat cancer patients relies heavily on ionizing radiation and chemotherapeutic drugs that severely damage DNA. Tumor cells' responses to such treatments are heavily influenced by their environment: Physical contacts with structural elements such as the extracellular matrix, associations with resident and transitory benign cells such as fibroblasts and leukocytes, and...

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PMID: 22619305
DOI: 10.1158/1078-0432.ccr-11-0768

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