Article
[Hereditary forms of ovarian cancer].
Bulletin du cancer - 1 Apr 2012
de Pauw Antoine, Jolissaint Laurianne, Fréneaux Paul, Rouleau Etienne, Stoppa-Lyonnet Dominique, Buecher Bruno
Abstract excerpt
Approximately 5 to 10 % of all ovarian cancers arise in the setting of a major genetic predisposition. The two main hereditary forms of ovarian adenocarcinomas are the hereditary breast/ovarian cancers associated with a BRCA1 or BRCA2 gene mutation and the Lynch syndrome associated with a MLH1, MSH2, MSH6 or PMS2 gene mutation. Their identification and the characterization of a causative germline mutation are...
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