Article
Oncogenesis in ovarian cancer.
Acta obstetricia et gynecologica Scandinavica. Supplement - 1 Jan 1992
Børresen A L
Abstract excerpt
Tumorigenesis is a multistep process involving mutations of dominantly acting proto-oncogenes and mutations and loss-of-function mutations of tumor suppressor genes. Some of these mutations may be inherited, but most of them are acquired. Models for the sequential steps of the genetic changes involved in tumor development have been proposed for certain cancers, such as colon cancer. In the case of ovarian cancer,...
Topics
- Alleles
- Chromosome Mapping
- DNA, Neoplasm
- Female
- Gene Amplification
- Genes, Tumor Suppressor
- Genes, myc
- Genes, ras
- Humans
- Oncogenes
- Ovarian Neoplasms
- Proto-Oncogenes