Article
c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 14 Jun 2011
Li Yunqing, Li Angela, Glas Martin, Lal Bachchu, Ying Mingyao, Sang Yingying, Xia Shuli, Trageser Daniel, Guerrero-Cázares Hugo, Eberhart Charles G, Quiñones-Hinojosa Alfredo, Scheffler Bjorn, Laterra John
Abstract excerpt
The tyrosine kinase c-Met promotes the formation and malignant progression of multiple cancers. It is well known that c-Met hyperactivation increases tumorigenicity and tumor cell resistance to DNA damaging agents, properties associated with tumor-initiating stem cells. However, a link between c-Met signaling and the formation and/or maintenance of neoplastic stem cells has not been previously identified. Here,...
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