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Article

Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation.

Proceedings of the National Academy of Sciences of the United States of America - 15 May 2007

Mahajan Nupam P, Liu Yuanbo, Majumder Samarpan, Warren Maria R, Parker Carol E, Mohler James L, Earp H Shelton, Whang Young E

Abstract excerpt

Activation of the androgen receptor (AR) may play a role in androgen-independent progression of prostate cancer. Multiple mechanisms of AR activation, including stimulation by tyrosine kinases, have been postulated. We and others have recently shown involvement of activated Cdc42-associated tyrosine kinase Ack1 in advanced human prostate cancer. Here we provide the molecular basis for interplay between Ack1 and...

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Identifiers

PMID: 17494760
DOI: 10.1073/pnas.0700420104
PMCID: PMC1895968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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