Article
Genetic markers for knee osteoarthritis presence are not associated with disease progression - data from the IMI-APPROACH cohort.
PloS one - 1 Jan 2025
Bentvelzen Mieke L M, Welsing Paco M J, Moingeon Philippe, Mastbergen Simon C, Kloppenburg Margreet, Blanco Francisco J, Haugen Ida K, Berenbaum Francis, Uh Hae-Won, Jansen Mylène P, El Bouhaddani Said
Abstract excerpt
OBJECTIVE: Knee osteoarthritis (OA) is a heterogeneous disease with different endotypes and phenotypes, resulting in patients' varying clinical and structural progression. Several genomic markers have been associated with knee OA presence. This study aimed to find new associations of these genetic markers with knee OA progression and to investigate the risk of knee OA progression using a polygenic risk score...
Read the complete abstract on PubMedTopics
- Humans
- Osteoarthritis, Knee
- Disease Progression
- Male
- Female
- Polymorphism, Single Nucleotide