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Overexpression of the <i>MDR1</i> Gene Is Sufficient To Confer Increased Resistance to Toxic Compounds in <i>Candida albicans</i>

28 Mar 2006

Abstract excerpt

Overexpression of MDR1, which encodes a membrane transport protein of the major facilitator superfamily, is one mechanism by which the human fungal pathogen Candida albicans can develop increased resistance to the antifungal drug fluconazole and other toxic compounds. In clinical C. albicans isolates, constitutive MDR1 overexpression is accompanied by the upregulation of other genes, but it is not known if these...

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PMID: 16569853
DOI: 10.1128/aac.50.4.1365-1371.2006

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Overexpression of the <i>MDR1</i> Gene Is Sufficient To Confer Increased Resistance to Toxic Compounds in <i>Candida albicans</i>PMID 16569853Read ↗

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