Drug-Induced Regulation of the MDR1 Promoter in Candida albicans

doi:10.1128/aac.49.7.2785-2792.2005

Article

Drug-Induced Regulation of the MDR1 Promoter in Candida albicans

25 Jun 2005

Abstract excerpt

Resistance of Candida albicans to azole antifungal drugs is mediated by two types of efflux pumps, encoded by the MDR1 gene and the CDR gene family. MDR1 mRNA levels in a susceptible clinical isolate are induced by benomyl (BEN) but not by other drugs previously shown to induce MDR1. To monitor MDR1 expression under several conditions, the MDR1 promoter was fused to the Renilla reniformis luciferase reporter gene...

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