Article
Genome-wide association study of antibody response to smallpox vaccine.
Vaccine - 13 Jun 2012
Ovsyannikova Inna G, Kennedy Richard B, O'Byrne Megan, Jacobson Robert M, Pankratz V Shane, Poland Gregory A
Abstract excerpt
We performed a genome-wide association study (GWAS) of antibody levels in a multi-ethnic group of 1071 healthy smallpox vaccine recipients. In Caucasians, the most prominent association was found with promoter SNP rs10489759 in the LOC647132 pseudogene on chromosome 1 (p=7.77×10(-8)). In African-Americans, we identified eight genetic loci at p<5×10(-7). The SNP association with the lowest p-value (rs10508727,...
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