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Article

Next-generation sequencing technology in prostate cancer diagnosis, prognosis, and personalized treatment.

Urologic oncology - 1 Jun 2015

Yadav Shalini S, Li Jinyi, Lavery Hugh J, Yadav Kamlesh K, Tewari Ashutosh K

Abstract excerpt

Next-generation sequencing (NGS) of the genetic information of cancer cells has revolutionized the field of cancer biology, including prostate cancer (PCa). New recurrent alterations have been identified in PCa (e.g., TMPRSS2-ERG translocation, SPOP and CHD1 mutations, and chromoplexy), and many previous ones in well-established pathways have been validated (e.g., androgen receptor overexpression and mutations;...

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Source

Identifiers

PMID: 25791755
DOI: 10.1016/j.urolonc.2015.02.009

Genes

CHD1
ERG
PTEN
SPOP
TMPRSS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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