Article
Pyoderma gangrenosum in association with Janus kinase 2 (JAK2V617F) mutation.
Clinical and experimental dermatology - 1 Jan 2013
Palanivel J A, Macbeth A E, Levell N J
Abstract excerpt
Pyoderma gangrenosum (PG) commonly occurs in association with various haematological and inflammatory disorders. We report a new association, a Janus kinase (JAK)2 mutation, in a 63-year-old patient with PG. We hypothesise that PG occurs by direct activation of JAK along with signal transducers and activators of transcription (STAT), a common mechanism involved in the pathogenesis of inflammatory and...
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