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Article

Effect of estrogen on pseudomonas mucoidy and exacerbations in cystic fibrosis.

The New England journal of medicine - 24 May 2012

Chotirmall Sanjay H, Smith Stephen G, Gunaratnam Cedric, Cosgrove Sonya, Dimitrov Borislav D, O'Neill Shane J, Harvey Brian J, Greene Catherine M, McElvaney Noel G

Abstract excerpt

BACKGROUND: Women with cystic fibrosis are at increased risk for mucoid conversion of Pseudomonas aeruginosa, which contributes to a sexual dichotomy in disease severity. METHODS: We evaluated the effects of estradiol and its metabolite estriol on P. aeruginosa in vitro and in vivo and determined...

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PMID: 22607135
DOI: 10.1056/NEJMoa1106126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22607135-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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