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Article

Effect of estrogen on pseudomonas mucoidy and exacerbations in cystic fibrosis.

The New England journal of medicine - 24 May 2012

Chotirmall Sanjay H, Smith Stephen G, Gunaratnam Cedric, Cosgrove Sonya, Dimitrov Borislav D, O'Neill Shane J, Harvey Brian J, Greene Catherine M, McElvaney Noel G

Abstract excerpt

BACKGROUND: Women with cystic fibrosis are at increased risk for mucoid conversion of Pseudomonas aeruginosa, which contributes to a sexual dichotomy in disease severity. METHODS: We evaluated the effects of estradiol and its metabolite estriol on P. aeruginosa in vitro and in vivo and determined the effect of estradiol on disease exacerbations in women with cystic fibrosis. RESULTS: Estradiol and estriol induced...

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PMID: 22607135
DOI: 10.1056/NEJMoa1106126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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