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Article

Molecular and population analysis of natural selection on the human haptoglobin duplication.

Annals of human genetics - 1 Sept 2012

Rodriguez Santiago, Williams Dylan M, Guthrie Philip A I, McArdle Wendy L, Smith George Davey, Evans David M, Gaunt Tom R, Day Ian N M

Abstract excerpt

Haptoglobin binds free haemoglobin that prevents oxidative damage produced by haemolysis. There is a copy number variant (CNV) in the haptoglobin gene (HP) consisting of two alleles, Hp1 (no duplication), and Hp2 (1.7kb duplication involving two exons). The spread of the Hp2 allele is believed to have taken place under selective pressures conferred by malaria resistance. However, molecular evidence is lacking and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22607059
DOI: 10.1111/j.1469-1809.2012.00716.x
PMCID: PMC3963445

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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