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Article

Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3.

The Journal of cell biology - 28 Oct 2002

Heremans Yves, Van De Casteele Mark, in't Veld Peter, Gradwohl Gerard, Serup Palle, Madsen Ole, Pipeleers Daniel, Heimberg Harry

Abstract excerpt

Regulatory proteins have been identified in embryonic development of the endocrine pancreas. It is unknown whether these factors can also play a role in the formation of pancreatic endocrine cells from postnatal nonendocrine cells. The present study demonstrates that adult human pancreatic duct cells can be converted into insulin-expressing cells after ectopic, adenovirus-mediated expression of the class B basic...

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Source

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Identifiers

PMID: 12403815
DOI: 10.1083/jcb.200203074
PMCID: PMC2173047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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