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Article

Rescue of misrouted GnRHR mutants reveals its constitutive activity.

Molecular endocrinology (Baltimore, Md.) - 1 Jul 2012

Janovick Jo Ann, Pogozheva Irina D, Mosberg Henry I, Cornea Anda, Conn P Michael

Abstract excerpt

G protein-coupled receptors (GPCR) play central roles in almost all physiological functions, and mutations in GPCR are responsible for over 30 hereditary diseases associated with loss or gain of receptor function. Gain of function mutants are frequently described as having constitutive activity (CA), that is, they activate effectors in the absence of agonist occupancy. Although many GPCR have mutants with CA, the...

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Identifiers

PMID: 22595961
DOI: 10.1210/me.2012-1089
PMCID: PMC3385788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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