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Article

Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10

17 May 2012

Abstract excerpt

BACKGROUND: MicroRNAs (miRNAs) are post-transcriptional regulators involved in numerous biological processes including the pathogenesis of Alzheimer's disease (AD). A key gene of AD, ADAM10, controls the proteolytic processing of APP and the formation of the amyloid plaques and is known to be regulated by miRNA in hepatic cancer cell lines. To predict miRNAs regulating ADAM10 expression concerning AD, we...

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PMID: 22594617
DOI: 10.1186/1471-2350-13-35

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