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Article

microRNA 221 Targets ADAM10 mRNA and is Downregulated in Alzheimer’s Disease

10 Oct 2017

Abstract excerpt

ADAM10 is the α-secretase that cleaves amyloid-β protein precursor in the non-amyloidogenic pathway in Alzheimer's disease (AD) and is known to be regulated by different microRNAs (miRNAs), which are post-transcriptional regulators related to several biological and pathological processes, including AD. Here we proposed to explore and validate miRNAs that have direct or indirect relations to the AD pathophysiology...

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PMID: 29036829
DOI: 10.3233/jad-170592

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