Human antibody targeting Vibrio cholerae O1 O-specific polysaccharide induces an amotile hypovirulent bacterial phenotype: mechanism of protection against cholera.

doi:10.1128/mbio.02235-25

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Human antibody targeting Vibrio cholerae O1 O-specific polysaccharide induces an amotile hypovirulent bacterial phenotype: mechanism of protection against cholera.

mBio - 8 Oct 2025

Verma Smriti, Cetinbas Murat, Kelly Meagan, Senger Stefania, Faherty Christina S, Janardhanan Jeshina, Wagh Chanchal R, Bhuiyan Taufiqur Rahman, Chowdhury Fahima, Khan Ashraful Islam, Akter Aklima, Charles Richelle C, Harris Jason B, Calderwood Stephen B, Wrammert Jens, Waldor Matthew K, Asp Merrill, Tai Jung-Shen Benny, Yan Jing, Xu Peng, Kováč Pavol, Sadreyev Ruslan I, Qadri Firdausi, Ryan Edward T

Abstract excerpt

Antibodies targeting the O-specific polysaccharide (OSP) of Vibrio cholerae O1 are crucial determinants of protection against cholera. These antibodies agglutinate bacteria and, even in sub-agglutinating conditions, inhibit V. cholerae motility. To explore additional effects of OSP-specific antibodies, we examined the transcriptomic profiles of V. cholerae exposed to a human anti-OSP monoclonal antibody in the...

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Identifiers

PMID: 40937849
DOI: 10.1128/mbio.02235-25
PMCID: PMC12505965

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