Article
Nisin resistance is increased through GtcA mutation induced loss of cell wall teichoic acid N-acetylglucosamine modifications in Listeria monocytogenes.
International journal of food microbiology - 30 Jan 2025
Mandinyenya Toruvandepi, Wambui Joseph, Muchaamba Francis, Stevens Marc J A, Tasara Taurai
Abstract excerpt
Nisin resistance development is one of food safety challenges posed by Listeria monocytogenes, an important foodborne pathogen that causes human listeriosis. The GtcA flippase enzyme is functionally crucial in two separate pathways that glycosylate cell envelope wall teichoic acids (WTA) with N-acetylglucosamine (NAG) and lipoteichoic acids (LTA) with galactose, respectively. This study investigated phenotypic...
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