Article
A gene-family analysis of 61 genetic variants in the nicotinic acetylcholine receptor genes for insulin resistance and type 2 diabetes in American Indians.
Diabetes - 1 Jul 2012
Yang Jingyun, Zhu Yun, Cole Shelley A, Haack Karin, Zhang Ying, Beebe Laura A, Howard Barbara V, Best Lyle G, Devereux Richard B, Henderson Jeffrey A, Henderson Patricia, Lee Elisa T, Zhao Jinying
Abstract excerpt
Cigarette smoking is a risk factor for type 2 diabetes. Genetic variants in the nicotinic acetylcholine receptor (nAChR) genes have been associated with smoking phenotypes and are likely to influence diabetes. Although each single variant may have only a minor effect, the joint contribution of multiple single nucleotide polymorphisms (SNPs) to the occurrence of disease may be larger. In this study, we conducted a...
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