Article
Lack of support for association between the copy number variants in the FCGR locus and schizophrenia: a case control study.
Neuroscience letters - 1 Aug 2012
Zhao Arman, Xiang Yuqian, Xu Jiawei, Li Qiaoli, Wang Lei, Xing Qinghe, Zhang Zhou, Liu Yun, Feng Guoyin, He Lin, Zhao Xinzhi
Abstract excerpt
The missing heritability of polygenic schizophrenia after genome-wide association studies (GWAS) can be potentially accounted for by the fact that most dynamic multiallelic copy number variants (CNVs) overlap segmental duplications (SDs). The FCGR locus covers this category of complex CNVs and it has long been postulated to harbor variants conferring the risk of schizophrenia. However, such association remains...
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