Article
Copy number variants in German patients with schizophrenia.
PloS one - 1 Jan 2013
Priebe Lutz, Degenhardt Franziska, Strohmaier Jana, Breuer René, Herms Stefan, Witt Stephanie H, Hoffmann Per, Kulbida Rebecca, Mattheisen Manuel, Moebus Susanne, Meyer-Lindenberg Andreas, Walter Henrik, Mössner Rainald, Nenadic Igor, Sauer Heinrich, Rujescu Dan, Maier Wolfgang, Rietschel Marcella, Nöthen Markus M, Cichon Sven
Abstract excerpt
Large rare copy number variants (CNVs) have been recognized as significant genetic risk factors for the development of schizophrenia (SCZ). However, due to their low frequency (1∶150 to 1∶1000) among patients, large sample sizes are needed to detect an association between specific CNVs and SCZ. So far, the majority of genome-wide CNV analyses have focused on reporting only CNVs that reached a significant P-value...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
