Article
The HDAC inhibitor Givinostat modulates the hematopoietic transcription factors NFE2 and C-MYB in JAK2(V617F) myeloproliferative neoplasm cells.
Experimental hematology - 1 Aug 2012
Amaru Calzada Ariel, Todoerti Katia, Donadoni Luca, Pellicioli Anna, Tuana Giacomo, Gatta Raffaella, Neri Antonino, Finazzi Guido, Mantovani Roberto, Rambaldi Alessandro, Introna Martino, Lombardi Luigia, Golay Josée
Abstract excerpt
We investigated the mechanism of action of the histone deacetylase inhibitor Givinostat (GVS) in Janus kinase 2 (JAK2)(V617F) myeloproliferative neoplasm (MPN) cells. GVS inhibited colony formation and proliferation and induced apoptosis at doses two- to threefold lower in a panel of JAK2(V617F) MPN compared to JAK2 wild-type myeloid leukemia cell lines. By global gene expression analysis, we observed that at 6...
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