Article
Interleukin-8 secretion by ovarian cancer cells increases anchorage-independent growth, proliferation, angiogenic potential, adhesion and invasion.
Cytokine - 1 Jul 2012
Wang Yue, Xu Rui Cheng, Zhang Xiao Lei, Niu Xiu Long, Qu Ye, Li Ling Zhi, Meng Xiang Yan
Abstract excerpt
It has been shown that IL-8 is elevated in ovarian cyst fluid, ascites, serum, and tumor tissue from ovarian cancer (OVCA) patients, and increased IL-8 expression correlates with poor prognosis and survival. However, the exact role that IL-8 plays in this malignancy or whether IL-8 can regulate malignant behavior has not been established. Here we demonstrate that overexpression of IL-8 in non-IL-8-expressing...
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