Article
mda-7/IL-24 expression inhibits breast cancer through upregulation of growth arrest-specific gene 3 (gas3) and disruption of β1 integrin function.
Molecular cancer research : MCR - 1 Jun 2013
Li You-Jun, Liu Guodong, Li Yanmei, Vecchiarelli-Federico Laura M, Liu Jeff C, Zacksenhaus Eldad, Shan Sze W, Yang Burton B, Li Qi, Dash Rupesh, Fisher Paul B, Archer Michael C, Ben-David Yaacov
Abstract excerpt
Melanoma differentiation-associated gene (MDA)-7)/interleukin (IL)-24, a member of the IL-10 family of cytokines, inhibits growth of various human cancer cells, yet the underlying mechanism is largely unknown. Here, we report that mda-7/IL-24 efficiently suppresses the development of rat mammary tumors in vivo. Microarray analysis for genes differentially expressed in rat mammary tumor cells overexpressing...
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