Article
Aberrant methylation of H19-DMR acquired after implantation was dissimilar in soma versus placenta of patients with Beckwith-Wiedemann syndrome.
American journal of medical genetics. Part A - 1 Jul 2012
Higashimoto Ken, Nakabayashi Kazuhiko, Yatsuki Hitomi, Yoshinaga Hokuto, Jozaki Kosuke, Okada Junichiro, Watanabe Yoriko, Aoki Aiko, Shiozaki Arihiro, Saito Shigeru, Koide Kayoko, Mukai Tsunehiro, Hata Kenichiro, Soejima Hidenobu
Abstract excerpt
Gain of methylation (GOM) at the H19-differentially methylated region (H19-DMR) is one of several causative alterations in Beckwith-Wiedemann syndrome (BWS), an imprinting-related disorder. In most patients with epigenetic changes at H19-DMR, the timing of and mechanism mediating GOM is unknown. To clarify this, we analyzed methylation at the imprinting control regions of somatic tissues and the placenta from two...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.