Article
Characterization of DNA methylation errors in patients with imprinting disorders conceived by assisted reproduction technologies.
Human reproduction (Oxford, England) - 1 Aug 2012
Hiura Hitoshi, Okae Hiroaki, Miyauchi Naoko, Sato Fumi, Sato Akiko, Van De Pette Mathew, John Rosalind M, Kagami Masayo, Nakai Kunihiko, Soejima Hidenobu, Ogata Tsutomu, Arima Takahiro
Abstract excerpt
BACKGROUND: There is an increased incidence of rare imprinting disorders associated with assisted reproduction technologies (ARTs). The identification of epigenetic changes at imprinted loci in ART infants has led to the suggestion that the techniques themselves may predispose embryos to acquire imprinting errors and diseases. However, it is still unknown at what point(s) these imprinting errors arise, or the...
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