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Article

Placentas from pregnancies conceived by IVF/ICSI have a reduced DNA methylation level at the H19 and MEST differentially methylated regions†

22 Jan 2013

Abstract excerpt

STUDY QUESTION: Does IVF/ICSI have an effect on the epigenetic regulation of the human placenta? SUMMARY ANSWER: We found a reduced DNA methylation level at the H19 and MEST differentially methylated regions (DMRs), and an increased RNA expression of H19 in placentas from pregnancies conceived by IVF/ICSI when compared with placentas from spontaneous conception. WHAT IS KNOWN ALREADY: Changes in fetal environment...

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PMID: 23343754
DOI: 10.1093/humrep/des459

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