Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The dominant-negative inhibition of double-stranded RNA-dependent protein kinase PKR increases the efficacy of Rift Valley fever virus MP-12 vaccine.

Journal of virology - 1 Jul 2012

Lihoradova Olga, Kalveram Birte, Indran Sabarish V, Lokugamage Nandadeva, Juelich Terry L, Hill Terence E, Tseng Chien-Te K, Gong Bin, Fukushi Shuetsu, Morikawa Shigeru, Freiberg Alexander N, Ikegami Tetsuro

Abstract excerpt

Rift Valley fever virus (RVFV), belonging to the genus Phlebovirus, family Bunyaviridae, is endemic to sub-Saharan Africa and causes a high rate of abortion in ruminants and hemorrhagic fever, encephalitis, or blindness in humans. MP-12 is the only RVFV strain excluded from the select-agent rule and handled at a biosafety level 2 (BSL2) laboratory. MP-12 encodes a functional major virulence factor, the NSs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing
Share to Chemokines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to eIF-2 Kinase

Share to Interleukin-17

Share to Interleukin-5

Share to Vero Cells

Share to Viral Nonstructural Proteins

Share to Viral Vaccines

Source

Open in PubMed Open full text

Identifiers

PMID: 22573861
DOI: 10.1128/JVI.00778-12
PMCID: PMC3416293

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The dominant-negative inhibition of double-stranded RNA-dependent protein kinase PKR increases the efficacy of Rift Valley fever virus MP-12 vaccine.PMID 22573861Read ↗

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and EfficacySemantic proximity Read ↗

The Rift Valley fever (RVF) vaccine candidate 40Fp8 shows an extreme attenuation in IFNARKO mice following intranasal inoculationSemantic proximity Read ↗

Rift Valley Fever Virus Lacking the NSs and NSm Genes Is Highly Attenuated, Confers Protective Immunity from Virulent Virus Challenge, and Allows for Differential Identification of Infected and Vaccinated AnimalsSemantic proximity Read ↗

Genetic Evidence for an Interferon-Antagonistic Function of Rift Valley Fever Virus Nonstructural Protein NSsSemantic proximity Read ↗

NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase.Semantic proximity Read ↗

Evaluations of rationally designed rift valley fever vaccine candidate RVax-1 in mosquito and rodent modelsSemantic proximity Read ↗

Rift Valley Fever Virus MP-12 Vaccine Is Fully Attenuated by a Combination of Partial Attenuations in the S, M, and L SegmentsSemantic proximity Read ↗

Rift Valley Fever Virus NSs Protein Promotes Post-Transcriptional Downregulation of Protein Kinase PKR and Inhibits eIF2α PhosphorylationSemantic proximity Read ↗

Characterization of Rift Valley Fever Virus MP-12 Strain Encoding NSs of Punta Toro Virus or Sandfly Fever Sicilian VirusSemantic proximity Read ↗

Rift Valley fever virus 78kDa envelope protein attenuates virus replication in macrophage-derived cell lines and viral virulence in miceSemantic proximity Read ↗

Rescue of infectious rift valley fever virus entirely from cDNA, analysis of virus lacking the NSs gene, and expression of a foreign gene.Semantic proximity Read ↗

p53 Activation following Rift Valley Fever Virus Infection Contributes to Cell Death and Viral ProductionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.